Objective To observe the clinical efficacy of different hook angles in hooking therapy for cervical spondylotic radiculopathy. Methods A total of 180 patients with cervical spondylotic radiculopathy were selected as the study subjects. They were divided into an observation group and a control group by using the random number table method, with 90 patients in each group. The control group was treated with hooking therapy at the new jiaji acupoint combination (C1 acupoint+C2 acupoint+C3 acupoint), and received one session of treatment with a single-soft 5-point hook angle disposable hook-di needle for hooking therapy. The observation group was treated at the new jiaji acupoint combination (C1 acupoint+C2 acupoint+C3 acupoint) with hook techniques of hooking therapy (including shallow single soft, light single soft, medium single soft, heavy single soft and double soft) combined with the manual simulation hook angle method. The corresponding hook angle was selected according to the patients' pain visual analogue scale (VAS) scores, and all the patients of observation group received one session of treatment with disposable hook-di needle for hooking therapy as well. The traditional Chinese medicine syndrome score, pain VAS score and neck pain severity score (assessed by the Northwick Park Neck Pain Questionnaire [NPQ]) were compared between the two groups before treatment, 2 hours after treatment and 7 days after treatment. Cervical range of motion (including cervical flexion, extension, left lateral flexion, right lateral flexion, left rotation and right rotation) and physiological curvature were compared between the two groups before treatment and 3 months after treatment. Clinical efficacy was compared between the two groups at 2 hours after treatment and 3 months after treatment, and the occurrence of treatment-related adverse reactions during treatment were observed in both groups. Results At 2 hours and 7 days after treatment, traditional Chinese medicine syndrome scores and pain VAS scores in both groups decreased successively and were lower than those before treatment, and the traditional Chinese medicine syndrome scores and pain VAS scores in the observation group were lower than those in the control group (P<0.05). At 2 hours and 7 days after treatment, NPQ scores in both groups were lower than those before treatment, and the NPQ score in the observation group was lower than that in the control group (P<0.05). At 3 months after treatment, cervical flexion, extension, left lateral flexion, right lateral flexion, left rotation, right rotation and physiological curvature in both groups were greater than those before treatment, and the cervical range of motion and physiological curvature in the observation group were greater than those in the control group (P<0.05). At 2 hours and 3 months after treatment, the clinical efficacy in the observation group was superior to that in the control group, and the total effective rate was higher (P<0.05). In the control group, 2 patients presented with mild needle hole bleeding on the day after treatment, which did not recur after intervention, and the needle holes healed favorably. No treatment-related adverse reactions were found in the other patients. Conclusion Compared with traditional hooking therapy, hooking therapy combined with the manual simulation pain hook angle method (hook angle, single and double soft, pain) for cervical spondylotic radiculopathy can improve patients' traditional Chinese medicine syndrome scores, relieve pain intensity, enhance cervical range of motion, and restore physiological curvature, with satisfactory clinical efficacy.