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目的探讨微血管密度(microvessel density,MVD)在胃癌前病变中的表达及其生物学意义。方法采用免疫组织化学SP法,检测75例不同病理类型胃活检组织中MVD的表达,观察患者不同临床病理特征下MVD的表达情况及其与EGFR的关系。结果 MVD在正常对照组、胃癌前病变组、早期胃癌组和进展期胃癌组中的表达均数分别为35.500±7.348、59.765±6.987、78.600±18.669和108.063±22.210,呈逐渐增加趋势,各组的表皮生长因子受体(EGFR)的表达也呈逐渐增加趋势,MDV与EGFR值呈正相关(r=0.772,r<0.01)。结论胃癌及癌前病变组织中MVD和EGFR存在过度表达,两者呈正相关,可作为判断胃癌前病变患者病情及预后的参考指标。
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胃癌前病变微血管密度的表达及其临床意义
Expression of microvessel density( MVD) in precancerous lesions of gastric cancer and its clinical significance
微创医学 201104期 页码：296-298
作者机构：广西医科大学第一附属医院老年消化科； 广西医科大学第一附属医院病理科
基金信息：基金项目: 广西卫生厅科研立项课题( 基金号: 桂卫Z2005032)
收稿日期: 2011-03-19
- 中文简介
- 英文简介
- 参考文献
Objective To observe the expression of microvessel density ( MVD) in precancerous disease and its clinical significance． Methods The expression of MVD were detected in 75 gastrosamples by immunohistochemical method，and its relationship with epidermal growth factor receptor ( EGFR) were explored． Results The expression of MVD in the normal group，precancerous lesions of gastric cancer group， early gastric carcinoma group and advanced gastric cancer group were gradual increased in the trend( 35． 500 ± 7． 348，59． 765 ± 6． 987，78． 600 ± 18． 669，and 108． 063 ± 22． 210，respectively) ， so was the expression of EGFR． The relationship of MVD and EGFR were positively correlated． Conclusion MVD and EGFR are over expressed and are positive related in precancerous lesions of gastric cancer and gastric carcinoma tissues， suggesting both can act as predicator for prognosis of precancerous lesions of gastric cancer and gastric carcinoma．
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