Objective To observe the clinical effect of comprehensive traditional Chinese medicine techniques combined with isthmic bone grafting under intervertebral foraminal endoscopy and percutaneous pedicle screw internal fixation for the treatment of lumbar spondylyosis in young patients. Methods A total of 30 young patients with lumbar spondylolysis admitted to the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine from June 2015 to October 2022 were selected. The patients were divided into observation group (15 cases) and control group (15 cases) by random number table method. Both groups underwent isthmic bone grafting combined with pedicle screw internal fixation under intervertebral foraminal endoscopy. Additionally, the observation group received comprehensive traditional Chinese medicine treatment. The two groups were compared in terms of operation time, intraoperative blood loss, postoperative ambulation time, postoperative hospital stay, visual analogue scale (VAS) score, and lumbar Oswestry disability index (ODI) score. Results There was no statistically significant difference in the operation time and intraoperative blood loss between the two groups (all P>0.05). The observation group had an earlier postoperative ambulation time and a shorter postoperative hospital stay compared to the control group, with statistically significant differences (all P<0.05). In terms of pain, there was no significant difference in VAS score between the two groups (P>0.05). The VAS of both groups decreased significantly over time (P<0.05). Moreover, there was an interaction effect between intervention and time (P<0.05). In terms of lumbar dysfunction, the ODI scores did not show a significant difference between the two groups (P>0.05). The ODI scores of both groups demonstrated a downward trend as time progressed (P<0.05). Additionally, a interaction effect was found between the different treatment regimens and time (P<0.05). Conclusion The combination of comprehensive traditional Chinese medicine techniques and minimally invasive surgery for treating lumbar spondylyosis in young patients is effective in relieving pain symptoms, accelerating the recovery of lumbar function, and reducing the hospital stay, which is worthy of promotion and application.