Objective To investigate the efficacy of single-port hybrid thoracoscopic lobectomy and total thoracoscopic lobectomy for high-risk pulmonary nodules based on propensity score matching. Methods A retrospective analysis was conducted on the clinical data of 185 patients diagnosed with high-risk pulmonary nodules. According to the order of admission time, patients were divided into a control group (n=90) who underwent total thoracoscopic lobectomy, and a study group (n=95) who received single-port hybrid thoracoscopic lobectomy. Following 1∶1 propensity score matching, the surgical duration, intraoperative blood loss, postoperative thoracic drainage volume, hospital stay, postoperative pain scores, and occurrence of postoperative complications were compared between the two groups. Results Following propensity score matching, no statistically significant differences were observed in baseline information between the two groups (P>0.05). Compared with the control group, the study group had shorter surgical duration, less intraoperative blood loss, shorter hospital stay, lower visual analogue scale scores on postoperative day 1 and day 3, and lower overall incidence of complications (P<0.05). However, there was no statistically significant difference in postoperative thoracic drainage volume between the two groups (P>0.05). Conclusion Compared with total thoracoscopic lobectomy in the treatment of patients with high-risk pulmonary nodules, single-port hybrid thoracoscopic lobectomy can effectively reduce intraoperative blood loss, shorten hospital stay, alleviate postoperative pain, and result in fewer complications; thus it is worthy of clinical application and popularization.

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