微创医学

【摘要】目的探讨突出物内注射糜蛋白酶治疗腰椎间盘突出症的临床疗效。方法146例腰椎间盘突出症患者随机分为对照组（71例）和观察组（75例）。对照组突出物内注射胶原酶，观察组突出物内注射糜蛋白酶。出院时评定疗效，出院6个月后回访再一次评定疗效。结果术后第4天评比疗效，对照组总有效率为49.3%（35/71），观察组32.0%（24/75），两组比较，差异有统计学意义（P＜0.05）。术后6个月随访评比1次疗效，总有效率对照组为83.1%（59/71），观察组为80.0%（60/75），两组比较，差异无统计学意义（P＞0.05）。结论突出物内注射糜蛋白酶治疗腰椎间盘突出症是一种费用低、痛苦小、安全、疗效较好的微创治疗方法。

【Abstract】 ObjectiveTo explore the clinical efficacy of intrahenial injection with chymotrypsin for treatment of lumbar intervertebral disc hemiation. MethodsA total of 146 patients with lumber intervertebral disc herniation were randomly divided into control group (n=71) and observation group (n=75). Intrahenial injection with collagenase was performed in the control group and intrahenial injection with chymotrypsin in the observation group. The efficacy was assessed when discharge and followup after 6 months of discharge. ResultsThe efficacy was assessed at the fourth day after operation, the total effective rate of the control group and the observation were 49.3%（35/71） and 32.0%（24/75）respectively，and there was significant difference between the two groups（χ2=8.052, P＜0.01）. The efficacy was assessed again after 6 months of operation, the total effective rate of the control group and the observation were 83.1%（59/71）and 80.0%（60/75）respectively，and there was no significant difference between the two groups（χ2=0.971,P＞0.05）. ConclusionFor lumbar intervertebral disc hemiation, intrahenial injection with chymotrypsin is a minimally traumatic approach with low cost, less pain, safety and good efficacy.

无