【Abstract】 ObjectiveTo investigate the efficacy of different surgical timings and highrisk factors for severe acute biliary pancreatitis (SABP). MethodsA retrospective analysis was conducted in 79 patients with SABP who underwent surgical treatment in our hospital. The patients were divided into early surgery group (n=44) and delayed surgery group (n=35) according to the surgical timing. The operative index, mortality rate, incident rate of complications and recurrence rate were compared between the two groups.The 79 patients with SABP and other 85 patients with nonbiliary acute pancreatitis were enrolled as SABP group and non SABP group respectively, then the general data was compared between the two groups, and logistic regression analysis was conducted to explore the highrisk factors of SABP. ResultsThere were no significant differences in the time for abdominal pain relief, time for alanine aminotransferase normalization, hospital stay, mortality and incident rate of complications between the early surgery group and the delayed surgery group (P＞0.05). But the recurrence rate of the early surgery group was significantly lower than that of the delayed surgery group［9.09% (4/44) vs. 28.57%（10/35）, P＜0.05］. The result of logistic regression analysis showed that drinking, blood albumin, blood lipid, serum creatinine and body mass index were the highrisk factors of SABP. ConclusionClinical treatment of patients with SABP, surgical timing and personalized therapeutic regimen should be chosen reasonably according to the individual condition of patients so that the surgical effect can be guaranteed. The early diagnosis and treatment of disease should be strengthened according to the highrisk factors for improving the prognosis of SABP.

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