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小剂量咪唑安定在小儿腹腔镜疝气手术中的应用研究
Application of small-dose midazolam to laparoscopic operation for pediatric hernia

微创医学 201712卷06期 页码:769-771+822

作者机构:广西医科大学第六附属医院暨玉林市第一人民医院,玉林市537000

基金信息:

DOI:DOI:10.11864/j.issn.1673.2017.06.13

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目的研究复合应用小剂量咪唑安定对小儿腹腔镜疝气手术术中麻醉深度及术后苏醒的影响。方法选择择期行小儿腹腔镜下内环口缝扎术的患者80例,随机分为两组,每组40例。观察组诱导中用咪唑安定0.05 mg/kg+丙泊酚4 mg/kg镇静,对照组诱导中用丙泊酚4 mg/kg镇静,两组其余镇痛药、肌松药种类及剂量均相同,术中均仅用七氟醚吸入维持麻醉。观察并比较两组患儿在麻醉诱导前后和手术开始前后的心率、血压变化,并观察有无苏醒期躁动等情况。结果两组的手术时间、麻醉时间、拔管时间和复苏室停留时间比较,差异均无统计学意义(P>0.05)。对照组七氟烷用量明显高于观察组,苏醒时间明显长于对照组,躁动评分低于对照组,差异均有统计学意义(P<0.05)。结论复合应用小剂量咪唑安定对小儿腹腔镜下疝气手术的术后苏醒时间影响不大,且可对抗焦虑,增强麻醉效果,减少术后躁动。
ObjectiveTo investigate the effect of small-dose midazolam on intraoperative anesthetic depth and postoperative recovery in laparoscopic operation of pediatric hernia. MethodsEighty children undergoing selective laparoscopic ligation of internal ring were enrolled and randomly divided into two groups, with 40 cases in each group. Anesthesia induction with 0.05 mg/kg of midazolam and 4mg/kg of propofol was conducted in the observation group, and 4mg/kg of propofol in the control group. Administration of other analgesics and muscle relaxants with the same type and dosage were performed in both group. Inhalation of sevoflurane was used as the anesthesia maintenance during operation. Before and after anesthesia induction or operation, the blood pressure and heart rate were observed and compared between the two groups, and the emergence agitation was also observed. ResultsThere were no significant differences in operative duration, anesthetic duration, duration for extubation and recovery room stay between the two groups(all P>0.05). The consumption of sevoflurane in the control group was significantly more than that in the observation group, but the duration for recovery was shorter and agitation score was lower in the observation group compared to the control group(all P<0.05). ConclusionCombination of small-dose midazolam has little effect on the duration for postoperative recovery in laparoscopic operation of pediatric hernia, and can alleviate the anxiety, enhance the anesthetic effect and reduce postoperative restlessness.

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