ObjectiveTo investigate the effect of ischemic postconditioning(IPC) on the prognosis of patients with ST-segment elevation myocardial infarction(STEMI) undergoing percutaneous coronary intervention(PCI). MethodsNinety-two patients definitely diagnosed as STEMI were enrolled, and were divided into IPC group (n=44) and routine PCI group(n=48) using random number table. All patients underwent PCI for corresponding infarction related artery. In the IPC group, 30 seconds of reperfusion followed by 30 seconds of reocclusion(achieved by repeated low-pressure inflation and deflation of balloon) was conducted within 1 minute after reperfusion for three times, then continuous reperfusion was performed. The routine PCI group received the treatment according to Chinese PCI guideline.The clinical baseline data and surgical data of patients were collected in detail. Follow-up of 1 year was performed in all subjects with the major cardiovascular adverse events (MACE) as the end point.Multivariate Cox proportional hazards regression model was used to investigate the incidence of MACE in both groups. ResultsThere were no significant differences between the two groups in the age, sex, baseline LVEF and FS levels, BMI, infarction site, proportion of single-vessel disease median total ischemic duration, the median D-to-B time and TIMI flow before and after operation（P＞0.05）. During the 1-year follow-up, 8 cases were lost and the incidence of loss to follow-up was 8.7%. Twenty-one MACE events occurred during follow-up, including 8 cases (19.5%) in IPC group and 13 cases (30.2%) in PCI group. Multivariate Cox regression analysis showed that the incidence of MACE in the IPC group was lower than that in the routine PCI group, but no significant difference was observed（P＞0.05）. There was no significant difference in the rate of rehospitalization due to heart failure between the IPC group and routine PCI group（P＞0.05）. ConclusionIPC fails to reduce the 1-year incidence of MACE in the patients with STEMI undergoing primary PCI.

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