ObjectiveTo investigate the correlation of genetic polymorphism at the MYD88 (myeloid differentiation factor 88) locus rs7744 and MRI findings in the ischemic stroke patients with wind-phlegm and blood stasis syndrome. MethodsA total of 631 ischemic stroke patients with wind-phlegm and blood stasis syndrome who were hospitalized in the First Affiliated Hospital of Guangxi University of Chinese Medicine were enrolled. Head MRI was conducted for collecting the data including the location, size and number of lesions, and the effect of the lesions on the surrounding tissues. The genotyping was assessed for single nucleotide polymorphism at the MYD88 locus rs7744 by Sequenom MassARRAY technique. PLINK software was used for statistical analysis. Results(1)The genetic polymorphism at the MYD88 locus rs7744 was not statistically correlated with the lesions located in the lobe of brain, corona radiata, thalamus and cerebellum (all P＞0.05), and was statistically correlated with the basal ganglia (P＜0.05) and brain stem (P＜0.05) was found in the additive model, recessive model and allele model).（2）The genetic polymorphism at the MYD88 locus rs7744 was not statistically correlated with the occurrence of the major infarction and small infarction (all P＞0.05) , and was statistically correlated with the moderate infarction(P＜0.05) was found in the additive model, recessive model, and allele model). （3）The genetic polymorphism at the MYD88 locus rs7744 was not statistically correlated with the multiple lesions and the effect of the lesions on the surrounding tissues (all P＞0.05). ConclusionThe genetic polymorphism at the MYD88 locus rs7744 is correlated with the incidence of ischemic stroke with wind-phlegm and blood stasis syndrome, the lesions located in the basal ganglia and brainstem and the incidence of the moderate infarction.

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