ObjectiveTo explore the efficacy and safety of arterial perfusion thrombolysis in the treatment of intramuscular calf venous thrombosis. MethodsThirty patients with intramuscular calf venous thrombosis were selected and divided into control group or observation group according to the random number table method, with 15 cases in each group. The control group was conducted with thrombolysis by dorsalis pedis vein injecting of urokinase, while the observation group was conducted with thrombolysis by femoral artery cannula and infusion of urokinase. The urokinase dosage, treatment time, clinical efficacy and the prevalence of complications, as well as the pain degree of gastrocnemius, calf circumference and the maximum diameter of intramuscular vein before and after treatment were compared between the two groups. ResultsThe observation group was found with less dosage of urokinase, shorter treatment time, a superior clinical efficacy compared to the control group (all P＜0.05). There was no statistically significant difference in the total effective rate between the two groups (P＞0.05). After treatment, the Visual Analogue Scale (VAS) score, calf circumference and the maximum diameter of intramuscular vein significantly decreased in both groups, with the changes more obvious in the observation group(all P＜0.05). Wound bleeding exhibited in one patient in the control group, but no obvious complication occurred in the observation group. ConclusionArterial perfusion thrombolysis is a safe and effective method for intramuscular calf venous thrombosis, with less dosage and shorter course of treatment, indicating it is worthy of clinical promotion.

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