ObjectiveTo observe the therapeutic effect of Changmai Tongbi decoction on acute myocardial infarction（AMI） patients after the percutaneous coronary intervention (PCI), and its effect on cardiac function. MethodsA total of 76 patients with acute myocardial infarction undergoing PCI were selected, and they were randomly divided into control group and Changmai Tongbi decoction group, with 38 cases in each group. The control group orally administrated aspirin and clopidogrel after PCI, based on which the Changmai Tongbi decoction group was additionally treated with Changmai Tongbi decoction. The therapeutic effect, TCM syndrome scores, the levels of high sensitivity C-reactive protein (hs-CRP) and cardiac function indicators, as well as the incidence of major adverse cardiovascular events (MACE) during the follow-up period were compared between the two groups. ResultsThe clinical efficacy of the Changmai Tongbi decoction group was significantly better than that of the control group (P＜0.05). After treatment, the TCM syndrome scores, the levels of hs-CRP, serum creatine kinase isoenzymes-MB (CK-MB), serum cardiac troponin Ⅰ(cTnⅠ) and N-terminal prohormone of brain natriuretic peptide (NT-proBNP) in the two groups all decreased, and the indexes mentioned above in the Changmai Tongbi decoction group were significantly lower than those in the control group (all P＜0.05). After half a year of follow-up, the incidence of MACE in the Changmai Tongbi decoction group was significantly lower than that in the control group (P＜0.05). ConclusionChangmai Tongbi decoction in treating AMI patients undergoing PCI can significantly relieve their clinical symptoms, improve prognosis, protect cardiac function, and help to prevent MACE.

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